The Mayo Clinic recently published a prospective study in the American Journal of Roentgenology involving 1,585 dense breast women, finding that combination of MBI/mammography found nearly 400% times more invasive cancers versus mammography alone, while also resulting in 50% reduction in biopsy rates.1

Of the cancers detected with MBI, and missed by mammography, lesions as large as 4cm were included. Additionally, over 80% of the invasive cancers identified with MBI, but missed by mammography, were still at the local stage (i.e., ‘node-negative’) where treatment options and prognosis is optimal.1

Case Study 1: Anonymous Female 1951

  • Patient with implants
  • Digital mammogram screening was conducted but images were unable to displace left implant
  • Moderate risk 16.28% per modified GAIL
  • MBI shows uptake in area hidden by implant on mammography
  • Bx positive for IDC

Case Study 2: Anonymous Female 1959

  • 54 y/o diagnosed with IDC
  • Mammogram was negative but due to breast tissue density additional surveillance was recommended
  • MBI clearly shows Tc-99m uptake in lesion

Case Study 3: Case 1A-(JO)

  • 67 y/o with dense mammogram
  • MBI is done for additional surveillance and shows intense focal tracer activity on the left breast
  • Correlative suspicious mass on targeted ultrasound
  • Biopsy reveals invasive ductal carcinoma
  • MBI, ultrasound and biopsy are done on same visit

Case Study 4: Case 2R-(LH)

  • 70 y/o female with a known right breast cancer for preoperative evaluation due to dense mammogram
  • Could not tolerate MRI
  • MBI shows focal intense tracer activity corresponding to known cancer with some minimal surrounding post biopsy uptake
  • There are no other suspicious findings

Case Study 5: Case 3A-(PN)

  • 81 y/o female. She is high risk
  • Wanted more screening but could not tolerate MRI
  • MBI shows intense focal tracer uptake in subareolar right breast
  • Correlative suspicious mass under ultrasound
  • Biopsy shows invasive ductal carcinoma
  • MBI, ultrasound and biopsy done on the same visit

Case Study 6: Case 4M-(DB)

  • 63 y/o female with extremely dense and complex mammogram
  • MBI is normal
  • Breast density makes Mammogram unreadable
  • Great example of negative predictive value of MBI

Case Study 7: Case 5J-(JH)

  • 53 y/o female with dense mammogram for additional screening
  • Mammogram is very dense but negative
  • MBI shows intense focal tracer accumulation at 2 o’clock
  • Targeted ultrasound reveals a correlative suspicious solid mass
  • Biopsy shows invasive ductal carcinoma
  • MBI, ultrasound and biopsy all done at the same visit
  1. Rhodes DJ, Hruska CB, Conners AL, et al. JOURNAL CLUB: Molecular Breast Imaging at Reduced Radiation Dose for Supplemental Screening in Mammographically Dense Breasts. American Journal of Roentgenology. 2015;204(2):241-251.